The SPRINT study (13) left us with the idea that “lower is better” and that it would be necessary to reconsider the guidelines, with the warning of a higher incidence of serious adverse events among patients with SBP targets <120 mmHg. The contribution by McEvoy et al (15) that motivates this editorial may help to explain this situation. (17-19) Coronary circulation is predominantly during diastole, so it is possible that a reduction in DBP beyond a certain limit could cause a decrease in coronary perfusion, a situation that would be aggravated if there were sub-clinical coronary obstructive lesions and/or if there were increased oxygen demand due to left ventricular hypertrophy secondary to hypertension. This situation would not occur in the self-regulating cerebrovascular circulation and therefore a J-curve response to cerebrovascular events would not be expected.
Aznavour sang for heads of state, Popes of the Catholic Church, European monarchs, as well as at humanitarian events. In response to the 1988 Spitak earthquake, he founded the Aznavour for Armenia charity with his lifelong friend, businessman Levon Sayan. In 2009 he was appointed Armenia’s ambassador to Switzerland, he remained as a delegate to the United Nations in Geneva. He has been married three times, and was a member of the Armenian community for many years.
Charles was married three times, and had in total six children. In his first marriage to Frenchwoman Michelline Rugel – whom he married in Paris on March 16, 1946 – he had Silk and Charles Aznavour Rugel. He separated from Michelline on March 27, 1952, after a relationship with Artlette Chez Lulu, since 1950.
Charles married a third time to Ulla Thorsell, on January 11, 1967 at the Flamingo Hotel in Las Vegas, United States, with whom he ended his days. With Ulla, Charles had his children Katia (his backup singer in his shows), Mischa and Nicolas Aznavour Thorsell.
His name served as inspiration for the character Char Aznable in the most important Japanese science fiction series, Mobile Suit Gundam. In Japan, he is one of the most cultured anime characters in history.
According to Víctor Goldgel (2014), the successful snob, that is to say the dandy, questions the ego’s integrity. In this way, Charles Baudelaire and Lucio V. Mansilla, as successful snobs, make the simulation a way of living. Mansilla follows Baudelaire: his desire of adopting different egos, of pretending to be what he is not. They use writing and photographic reproduction to destroy the unity of the writer’s image.
2In the causerie “Hallucination”, Mansilla (1963 : 40) openly acknowledges his madness and confesses to have seen ghosts and to have adopted different personalities. How can we explain his literary procedure? How does the author manage to assume other “selves” without losing the integrity of his person? Victor Goldgel’s (2014) reading of the victorious snob, the independent writer, will allow us to understand Mansilla’s emergence in an intellectual field where writers are not yet able to exercise their profession autonomously. For when Mansilla loses himself in extensive digressions and reaches the void, he manages to position himself as a fiction writer in a market where literature still has to respond to the political and economic interests of his time. Thus, as opposed to the Argentine author of the 80’s generation, whose autonomy is considered unthinkable (Jitrik, 1968), Mansilla stands as the “first (Argentine) fiction writer” (Contreras, 2014), a writer closer to the late twentieth century than to the previous times that did not know how to understand him1.
Between 1858 and 1860 he was Andral’s substitute professor in general pathology. In 1862 he gave a clinical course in mental diseases at Necker Hospital. In 1867 he replaced Andral as professor of general pathology and therapeutics. In 1869 he was appointed professor of medical clinic (fourth chair) at the Pitié, replacing Béhier. After his death he was replaced by Jaccoud (1883).
He published several articles in the Annales médico-psychologiques, the Archives générales de médecine (of which he became editor-in-chief), Union médicale, among other journals. He was a member of the Academy of Medicine, section of medical pathology since 1876, “Officier de l’Instruction publique” (1877), of the “Légion d’honneur” (1871). He married Marie Victoire Perrotin. They had several children.
In sciatica, flexion of the lower limb extended over the hip is painful, but if the knee is not bent, flexion is easy. It is also the sign that distinguishes sciatica from joint disorders.